GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs4660306 | 1 | rs1044717 | chr1:45976587 | CCDC163P | chr1:45960581-45965646:- | -0.57 | -7.3 | 1.52E-11 | Homocysteine levels |
| UCEC | cis | rs1577917 | 1 | rs10455158 | chr6:86672825 | SNHG5 | chr6:86386726-86388451:- | -0.42 | -4.96 | 1.9E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs2294008 | 1 | rs1045531 | chr8:143763547 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.18 | 6.94E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs1577917 | 1 | rs10455449 | chr6:86592226 | SNHG5 | chr6:86386726-86388451:- | -0.54 | -5.87 | 2.64E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs10455455 | chr6:86670214 | SNHG5 | chr6:86386726-86388451:- | -0.52 | -5.88 | 2.51E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs10455456 | chr6:86670322 | SNHG5 | chr6:86386726-86388451:- | -0.42 | -4.96 | 1.9E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs2294008 | 1 | rs1045547 | chr8:143763757 | PSCA | chr8:143761875-143764142:+ | 0.42 | 5.18 | 6.97E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs1045574 | chr8:143763958 | PSCA | chr8:143761875-143764142:+ | 0.43 | 5.39 | 2.62E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs1045605 | chr8:143764101 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.1 | 9.99E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs9473555 | 1 | rs10456622 | chr6:49396453 | MUT | chr6:49398994-49431031:- | 0.34 | 5.95 | 1.74E-8 | Folate pathway vitamin levels |
| UCEC | cis | rs10461617 | 1 | rs10461617 | chr5:56104308 | C5orf35 | chr5:56205103-56213010:+ | 0.55 | 6.17 | 5.86E-9 | Type 2 diabetes |
| UCEC | cis | rs9309473 | 1 | rs10496191 | chr2:73673798 | ALMS1P | chr2:73872046-73912692:+ | 0.54 | 6.5 | 1.06E-9 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs10496193 | chr2:73773503 | ALMS1P | chr2:73872046-73912692:+ | 0.51 | 6.09 | 9.0E-9 | Metabolite levels |
| UCEC | cis | rs1577917 | 1 | rs10498958 | chr6:86649705 | SNHG5 | chr6:86386726-86388451:- | 0.53 | 5.93 | 1.94E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs9815354 | 1 | rs1052501 | chr3:41925398 | ULK4 | chr3:41288091-42003660:- | -0.52 | -6.32 | 2.73E-9 | Diastolic blood pressure |